Studies of children and adults (mixed population) may be included if (1) data for children may be isolated, (2) ≥80% of the sample is ≤21 y old, or (3) the mean ☑.5 SD age is ≤21 y old Eligibility CriteriaĬhildren (≤21 y old) with acutely painful conditions and/or who are undergoing a painful medical procedureĪdults (>21 y old), animal studies, chronic pain conditions without acute pain We used EndNote (version X5 Clarivate Analytics, Philadelphia, PA) to manage records and remove duplicates. We also scanned reference lists (included studies and relevant reviews) and contacted 6 external content experts and the authors of ongoing research. In November 2018, we updated the search in Medline, Embase, CINAHL, Ei Compendex, Web of Science, the CADTH Web site, the TRIP database, and Google. We searched for gray literature via health technology assessment agency Web sites (Canadian Agency for Drugs and Technologies in Health and Turning Research Into Practice ), clinical trial registries ( ) and Web search engines (Google). host (EBSCOhost) Ovid PsycINFO Institute of Electrical and Electronic Engineers Xplore Ei Compendex via Engineering Village and Web of Science Core Collection via Clarivate Analytics ( Supplemental Information). A research librarian implemented a peer-reviewed 16 search strategy in October 2017 in ePub Ahead of Print, In-Process and Other Nonindexed Citations, Ovid Daily Medline Daily, and Ovid Medline Ovid Embase Wiley Cochrane Library Cumulative Index to Nursing and Allied Health Literature (CINAHL) Plus with full text via Elton B.
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